Amphiphysin expression in a case of occult cancer with paraneoplastic stiff‐person syndrome

The evaluation of the amphiphysin expression in the metastatic lesion was helpful for the diagnosis of paraneoplastic Stiff-Person syndrome associated with occult breast cancer. Our image may support to realize that the expression of amphiphysin in the metastatic lesion caused this rare symptom. Occult cancer is not rare in paraneoplastic syndromes, so we believe that the assessment of auto-antigen expression in the metastatic lesion may help our diagnosis and treatment. Conflict of interest: The authors declare no conflict of interest. Human studies: Human studies are in accordane with the ethical statement of the medical research for humans from Osaka Medical College. Animal studies: No animals were used in this study.