Study Of The Safety Profile Of Raw (Asodhita) And Cow'S Urine Processed (Gomutra Sodhita) Tubers Of Gloriosa Superba L. (Langali) In Albino Rats
INDIAN JOURNAL OF NATURAL PRODUCTS AND RESOURCES(2019)
摘要
Langali (Gloriosa superba L.) is a drug in upavisa varga (semi-poisonous drug) which has to undergo sodhana procedure before its therapeutic use. The present study was planned to assess the role of sodhana of Langali tuber by gomutra on its safety aspects in experimental animals, which is recommended by Ayurvedic Formulary of India. The therapeutic dose of Langali as per API is 125 to 250 mg/day. For the present study the higher dose i.e. 250 mg was selected. Wistar strain albino rats were used for the study. The animals were divided into seven groups and each group contained 12 animals (six male and six female). The study was done for 90 days followed by 30 days (total 120 days) recovery study. Various haematological, biochemical parameters and histopathology of the organs were studied. The study showed that sodhana process attenuates the toxicity producing potential of raw Langali. When processed with gomutra, langali root produces good spermatogenic effect while raw/asodhita langali hampers spermatogenesis at 10 times dose level. So it can be concluded that both raw and sodhita Langali found relatively safe up to 5 times therapeutic dose level.
更多查看译文
关键词
Gloriosa superba L, Gomutra, Langali, Sodhana, Toxicity, Upavisa
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要