Iron Bioavailability And Cardiopulmonary Function During Ascent To Very High Altitude

More than one hundred million people reside worldwide at altitudes in excess of 2500 m above sea level. In the millions more who sojourn at high altitude for recreational, occupational or military pursuits, hypobaric hypoxia drives physiological changes affecting the pulmonary circulation, haematocrit and right ventricle (RV) [1]. Coincident with these, maximal left ventricular (LV) stroke volume (SV) falls [2], with a reduction of 20% reported after a two-week stay at 4300 m [3].\n\nFootnotes \n\nThis manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.\n\nConflict of interest: Dr. Holdsworth has nothing to disclose.\n\nConflict of interest: Dr. Frise reports grants from British Heart Foundation, during the conduct of the study.\n\nConflict of interest: Dr. Bakker-Dyos has nothing to disclose.\n\nConflict of interest: Dr. Dorrington has nothing to disclose.\n\nConflict of interest: Dr. Woods has nothing to disclose.\n\nConflict of interest: Dr. Mellor has nothing to disclose.\n\nConflict of interest: Dr. Robbins reports grants from Vifor Pharma, outside the submitted work.\n\nConflict of interest: Dr. Christopher Boos I have no known conflict of interests to declare in relation to this submitted work.