Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2

Julia Kowal,Dongchun Ni,Scott M Jackson,Ioannis Manolaridis,Henning Stahlberg,Kaspar P Locher

Journal of Molecular Biology（2021）

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摘要

•Anticancer drugs interact with key amino acid residues in the binding pocket of ABCG2.•Substrate retains some mobility inside the drug-binding pocket of ABCG2.•Residues responsible for interactions with substrates were identified.•Structural flexibility of NBDs is reduced by substrate binding.

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ABCG2,BCRP,topotecan,mitoxantrone,tariquidar

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