The place of ceftazidime/avibactam and ceftolozane/tazobactam for therapy of haematological patients with febrile neutropenia

Daniela Clerici,Chiara Oltolini,Raffaella Greco,Marco Ripa,Fabio Giglio,Sara Mastaglio,Francesca Lorentino,Francesca Pavesi,Francesca Farina,Carmine Liberatore,Barbara Castiglioni,Chiara Tassan Din,Massimo Bernardi,Consuelo Corti,Jacopo Peccatori,Paolo Scarpellini,Fabio Ciceri,Antonella Castagna

International Journal of Antimicrobial Agents（2021）

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摘要

•Multidrug-resistant Gram-negative infections affect mortality in haematological patients•Multidrug-resistant Gram-negative bacteria colonisation is a risk factor for blood stream infection•Ceftazidime/avibactam and ceftolozane/tazobactam are active against carbapenem-resistant bacteria•Empirical therapy of febrile neutropenia should be tailored according to the colonisation status•A de-escalation approach is mandatory to preserve the activity of these new antibiotics

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关键词

Ceftazidime/avibactam,Ceftolozane/tazobactam,Multi-drug resistant Gram-negative blood-stream infections,Empirical therapy of febrile neutropenia,Haematopoietic stem cell transplantation

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