Effects of low-carbohydrate diet and ketogenic diet on glucose and lipid metabolism in type 2 diabetic mice

•Both low-carbohydrate and ketogenic diets are effective in lowering blood glucose levels.•The ketogenic diet promotes gluconeogenesis.•The low-carbohydrate diet inhibits gluconeogenesis by activating AMP-activated protein kinase.•The ketogenic diet but not the low-carbohydrate diet promotes hepatic lipid accumulation in diabetic mice.