The Kv7 Modulator, Retigabine, is an Efficacious Antiseizure Drug for Delayed Treatment of Organophosphate-induced Status Epilepticus

Bryan S Barker,Jay Spampanato,Hilary S McCarren, Kyle Berger,Cecelia E Jackson,David T Yeung,F Edward Dudek,John H McDonough

Neuroscience（2021）

引用 2|浏览4

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摘要

•The Kv7 channel agonist retigabine is a novel treatment option for OP-induced SE.•Retigabine with and without MDZ, attenuated electrographic seizure activity•The combination therapy of retigabine and MDZ provided moderate neuroprotection.

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关键词

nerve agent,soman,diisopropyl fluorophosphate,fluoro-Jade B,electroencephalogram,rat

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