Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding.

Mariusz Butkiewicz,Alice L. Rodriguez,Shane E. Rainey,Joshua Wieting,Vincent B. Luscombe,Shaun R. Stauffer,Craig W. Lindsley,P. Jeffrey Conn,Jens Meiler

user-5f8cf7e04c775ec6fa691c92（2019）

引用 4|浏览2

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摘要

As part of the G-protein coupled receptor (GPCR) family, metabotropic glutamate (mGlu) receptors play an important role as drug targets of cognitive diseases. Selective allosteric modulators of mGl...

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关键词

Metabotropic glutamate receptor,Metabotropic receptor,2-Methyl-6-(phenylethynyl)pyridine,Allosteric regulation,G protein-coupled receptor,Glutamate receptor,Receptor,Virtual screening,Biochemistry,Chemistry

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