Development of zirconium modified adenosine triphosphate functionalized monolith for specific enrichment of N-glycans

Huikai Shao,Liang Lai,Dongsheng Xu,Jacques Crommen,Qiqin Wang,Zhengjin Jiang

Journal of Chromatography A（2021）

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摘要

•A novel Zr(IV) modified adenosine triphosphate (ATP) functionalized monolith was prepared.•The ATP functionalized monolith was prepared viafacile one-pot polymerization.•Fluorescent labeled N-glycans were efficiently enriched by Zr(IV) modified monolith.•All five N-glycans from Ribonuclease B were successfully enriched.

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关键词

Adenosine triphosphate,Zr(IV)-ATP functionalized monolith,Enrichment of N-glycans,Immobilized metal affinity chromatography

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