Serine-Selective Bioconjugation.

Julien C. Vantourout,Srinivasa Rao Adusumalli,Kyle W. Knouse,Dillon T. Flood,Antonio Ramirez,Natalia M. Padial,Alena Istrate, Katarzyna Maziarz,Justine N. deGruyter,Rohan R. Merchant,Jennifer X Qiao,Michael A. Schmidt,Michael J. Deery,Martin D. Eastgate,Philip E. Dawson,Gonçalo J.L. Bernardes,Phil S. Baran

user-5f8cf7e04c775ec6fa691c92（2020）

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摘要

The first general method for the rapid, chemoselective, and modular functionalization of serine residues in native polypeptides is reported using a reagent platform based on P(V) oxidation state. T...

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关键词

Bioconjugation,Reagent,Serine,Combinatorial chemistry,Surface modification,Oxidation state,Chemistry,General method

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