1-MT grafted carboxymethyl chitosan and its nanoparticles: Preparation, characterization and evaluation

Jiaming Li,Lei Han,Siwen Zhan,Ran Li,Yaowen Wang,Tong Qiu,Xueqiong Zhang

European Journal of Pharmaceutical Sciences（2021）

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摘要

•Synthesizing CMCS-1MT nanoparticles with core-shell structure.•The nanoparticles release drugs with acid responsiveness.•The NPs can inhibit cancer cell growth through ER stress and mitochondrial apoptosis.

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关键词

1-Methyl-DL-tryptophan,Carboxymethyl chitosan,Nano drug-loading system,Endoplasmic reticulum stress,Cancer suppression

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