Senescent Mesenchymal Stem Cells: Disease Mechanism and Treatment Strategy.
Current molecular biology reports（2020）
Abstract
Senescent MSCs not only hamper tissue repair through cell senescence associated stem cell exhaustion, but also mediate tissue degeneration by initiating and spreading senescence-associated inflammation. It suggests new strategies of MSC-based cell therapy to remove, rejuvenate, or replace (3Rs) the senescent MSCs.
MoreTranslated text
Key words
Age-associated diseases,Cell senescence,Mesenchymal stem cells,Osteoarthritis,Replication stress,Senolytics
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined