An inhibitory and beneficial effect of chlorpromazine and promethazine (C + P) on hyperglycolysis through HIF-1α regulation in ischemic stroke
Brain research（2021）
Abstract
•A novel understanding of the neuroprotection mechanism of C + P post-stroke.•C + P confers neuroprotection partially dependent on inducing therapeutic hypothermia.•Neuroprotective effect of C + P may be due to inhibition of glucose metabolism.•HIF-1α may play an integral role in this overall molecular process.
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Key words
Ischemia/reperfusion,Stroke,Phenothiazines,Chlorpromazine and Promethazine (C+P),Pharmacological hypothermia,Hypoxia-induced factor-1α (HIF-1α)
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