Sugar Containing Compounds and Biological Activities of Lagochilus setulosus
MOLECULES(2021)
Abstract
Phytochemical investigation of the methanolic extract obtained from the aerial parts of Lagochilus setulosus (Lamiaceae) afforded the new compound 1-methoxy-3-O-beta-glucopyranosyl-alpha-l-oliose (1) together with five known glycosides, namely sitosterol-3-O-beta-glucoside (2), stigmasterol-3-O-beta-glucoside (3), pinitol (4), 6 beta-hydroxyl-7-epi-loganin (5), and chlorotuberoside (6). The structures of these compounds were elucidated by extensive spectroscopic analyses, especially HR-MS, 1D and 2D NMR spectroscopy. The in vitro cytotoxic activity of the methanolic extract and the isolated compounds was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and crystal violet (CV) staining assays. In addition, the antifungal activities of the components were evaluated against Botrytis cinerea, Septoria tritici, and Phytophthora infestans. The anthelmintic potential was determined against Caenorhabditis elegans nematodes. Neither the extract nor the isolated compounds showed promising activity in all the bioassays.
MoreTranslated text
Key words
Lamiaceae,Lagochilus setulosus,1-Methoxy-3-O-β,-glucopyranosyl-α,-l-oliose,NMR,HR-MS,anthelmintic,antifungal,cytotoxic
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined