Leishmania (V.) braziliensis infection promotes macrophage autophagy by a LC3B-dependent and BECLIN1-independent mechanism

Thabata Lopes Alberto Duque, Thamires Christinne de Souza Lopes Cruz Serrão, Antônio José da Silva Gonçalves,Eduardo Fonseca Pinto,Manoel Paes Oliveira-Neto,Claude Pirmez,Luiza de Oliveira Ramos Pereira,Rubem Figueiredo Sadok Menna-Barreto

Acta Tropica（2021）

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摘要

•In early infection, THP-1 macrophages cultured with Leishmania braziliensis delayed LC3 mobilization.•During late infection, the percentage of LC3+ cells increased in infected culture.•Autophagy induction, through rapamycin treatment or starvation, reduced infection at 24h.•Autophagy downregulation by LC3B but not BECLIN1 siRNA increased infection.

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关键词

Leishmania spp.,Leishmaniasis,Autophagy,Macrophages,LC3B,BECLIN1

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