Comparison Of Sedation Quality And Safety Of Detomidine And Romifidine As A Continuous Rate Infusion For Standing Elective Laparoscopic Ovariectomy In Mares

Objective To compare efficacy and safety of a continuous rate infusion of detomidine hydrochloride and romifidine hydrochloride for standing elective bilateral laparoscopic ovariectomy in mares.Study Design Blinded, randomized prospective clinical study.Animals Eighteen healthy mares presenting for elective bilateral ovariectomyMethods Mares were randomly assigned to one of two sedation protocols. Prior to surgery, baseline head height, heart rate, respiratory rate, and postural sway were recorded. An IV loading dose of alpha 2-agonist (46 mu g/kg romifidine or 13.9 mu g/kg detomidine) was administered. Standing sedation was maintained with a continuous rate infusion of the respective alpha 2-agonist (126 mu g/kg/h romifidine or 37.8 mu g/kg/h detomidine). Intraoperative measurements included respiratory rate, heart rate, head height, postural sway, and response to surgical stimulus. Postoperatively, fecal output was recorded, and pain scoring was performed using composite pain score and visual analog scales.Results Three of 18 horses required additional alpha-2 agonists: one detomidine and two romifidine and butorphanol. Head height during surgery was lower (p < .001) in mares receiving detomidine. Postural sway around the vertical axis was greater in mares sedated with detomidine rather than romifidine (p = .013). No differences were detected in intraoperative heart rate, postoperative pain scores or postoperative fecal output between sedation techniques.Conclusion Comparable scores for surgical stimulation and sedation were measured in both sedation groups. No differences in postoperative analgesia or manure production were identified.Clinical Significance Romifidine appears suitable as an alternative to detomidine and may limit ataxia and head drop in sedated horses.