Interaction Between Beta-Lactam Antibiotic And Phosphorus-Accumulating Organisms
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH(2021)
摘要
beta-Lactam antibiotics have been widely used in clinic due to strong antibacterial activity with mild adverse side effects and have been detected in the environment. In the enhanced biological phosphorus removal (EBPR) process, phosphorus-accumulating organisms (PAOs) play a major role. In this study, amoxicillin, aztreonam, and cefoperazone are the selected antibiotics that applied in investigating the interaction mechanism of beta-lactam antibiotics and PAO. The effects of beta-lactam antibiotics on PAOs were analyzed comprehensively from the aspects of antibiotic impacts on phosphorus removal rate, intracellular polymer, their toxicity to PAOs, and PAO impacts on the fate of beta-lactam antibiotics. It was found that the phosphorus removal rate of PAO increased by 19.21% and 15.75%, respectively at 10 mg/L amoxicillin and aztreonam, while cefoperazone had certain inhibition effect on phosphorus removal efficiency. Quantitative analysis shows that in the aerobic stage, three kinds of beta-lactam antibiotics could promote the synthesis of polyphosphates (poly-P). The degradation rates of three antibiotics were as follows: amoxicillin > aztreonam > cefoperazone. The fate characteristics of antibiotics provide a theoretical basis for environmental risk assessment. The toxic effects of three antibiotics were as follows: cefoperazone > aztreonam > amoxicillin according to the bacteriostatic test. It provided a scientific theoretical basis for systematically evaluating the biological toxicity of antibiotic pollutants.
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关键词
β, -Lactam antibiotics, Phosphorus-accumulating organisms (PAOs), Phosphorus removal rate, Intracellular polymers, Degradation modes, Toxic effect
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