Stereoselective Access To Polyfunctionalized Nine-Membered Heterocycles By Sequential Gold And Palladium Catalysis
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2021)
摘要
We report herein a gold and palladium sequential catalysis system to access furan-fused nine-membered heterocycles in high efficiency and enantioselectivity. In this one-pot procedure, easily accessible enynamides undergo cyclization to generate azadienes in situ that participate in enantioselective formal [5+4] cycloaddition with vinyl ethylene carbonates. Conformation-controlled highly diastereoselective derivatizations of these medium-sized rings, coupled with oxidative furan cleavage, have enabled the access to diverse densely-functionalized nine-membered lactams.
更多查看译文
关键词
[5+4] cycloaddition, enantioselectivity, gold catalysis, medium-sized heterocycle, palladium catalysis
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要