Use Of Ga-68-Fapi Pet/Ct For Evaluation Of Peritoneal Carcinomatosis Before And After Cytoreductive Surgery

A 55-year-old woman underwent F-18-FDG and Ga-68-FAPI PET/CT for tumor detection and staging under the prospective study NCT04416165. Both scans showed a mass lesion with increased tracer uptake in the pancreas. Moreover, Ga-68-FAPI PET/CT showed a greater number of abnormal foci in the mesentery and omentum than that shown with F-18-FDG. These abnormal foci were suspected to be metastases from pancreatic cancer. The patient subsequently underwent a cytoreductive surgery, and postoperative histopathology confirmed the diagnosis of acinar cell carcinoma of pancreas. Follow-up Ga-68-FAPI PET/CT (3 months after surgery) showed an excellent response with decreasing Ga-68-FAPI activity in the whole abdomen.