A Genetic Model Reveals Biological Features Of Neonatal Cd4 Helper Cells Undergone Homeostasis In Mice
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY(2021)
Abstract
CD4(+) T cells are essential for regulating effective immune response to pathogens and immune balance. Recent studies have demonstrated the unique features of T cells in neonate mice, such as more sensitive to antigen response and preference toward T helper 2 (Th2) response and regulatory T cells (Tregs) differentiation. However, the biological characteristics of neonatal age-derived CD4(+) T cells following homeostasis remain unclear. Here we utilized a lineage tracing model of TCR delta(CreER)R26(ZsGreen) to mark neonatal- and adult-derived CD4(+) T cells followed by a combination analysis of activation, proliferation, survival, and differentiation. Our results showed that neonatal CD4(+) T cells had higher capacity of activation, proliferation, apoptosis, and differentiation toward Th2 and T helper 17 (Th17) lineages, accompanied by a reduced potential for T helper 1 (Th1), T helper 9 (Th9), and Treg lineages. In contrast, tracked neonatal CD4(+) T cells exhibited similar characters of above-mentioned of tracked adult cells in adult mice. Therefore, our data support a natural requirement for CD4(+) T cells to acquire fully-equipped functional potentials of adult cells.
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Key words
neonate, adulthood, tracked T cells, homeostasis, differentiation
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