Comprehensive Comparative Effectiveness And Safety Of First-Line Beta-Blocker Monotherapy In Hypertensive Patients A Large-Scale Multicenter Observational Study

Evidence for the effectiveness and safety of the third-generation beta-blockers other than atenolol in hypertension remains scarce. We assessed the effectiveness and safety of beta-blockers as first-line treatment for hypertension using 3 databases in the United States: 2 administrative claims databases and 1 electronic health record-based database from 2001 to 2018. In each database, comparative effectiveness of beta-blockers for the risks of acute myocardial infarction, stroke, and hospitalization for heart failure was assessed, using large-scale propensity adjustment and empirical calibration. Estimates were combined across databases using random-effects meta-analyses. Overall, 118 133 and 267 891 patients initiated third-generation beta-blockers (carvedilol and nebivolol) or atenolol, respectively. The pooled hazard ratios (HRs) of acute myocardial infarction, stroke, hospitalization for heart failure, and most metabolic complications were not different between the third-generation beta-blockers versus atenolol after propensity score matching and empirical calibration (HR, 1.07 [95% CI, 0.74-1.55] for acute myocardial infarction; HR, 1.06 [95% CI, 0.87-1.31] for stroke; HR, 1.46 [95% CI, 0.99-2.24] for hospitalized heart failure). Third-generation beta-blockers were associated with significantly higher risk of stroke than ACE (angiotensin-converting enzyme) inhibitors (HR, 1.29 [95% CI, 1.03-1.72]) and thiazide diuretics (HR, 1.56 [95% CI, 1.17-2.20]). In conclusion, this study found many patients with first-line beta-blocker monotherapy for hypertension and no statistically significant differences in the effectiveness and safety comparing atenolol with third-generation beta-blockers. Patients on third-generation beta-blockers had a higher risk of stroke than those on ACE inhibitors and thiazide diuretics.