Impaired performance of SARS-CoV-2 antigen-detecting rapid diagnostic tests at elevated and low temperatures

Verena Haage,Edmilson Ferreira de Oliveira-Filho,Andres Moreira-Soto,Arne Kühne,Carlo Fischer,Jilian A Sacks,Victor Max Corman,Marcel A Müller,Christian Drosten,Jan Felix Drexler

Journal of Clinical Virology（2021）

引用 31|浏览7

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摘要

•Analytical sensitivity of SARS-CoV-2 Ag-RDTs ranges from 1.0 × 106-5.5 × 107 copies/mL.•Even short-term exposure to 37 °C reduces sensitivity of SARS-CoV-2 Ag-RDTs.•Elevated temperatures impair sensitivity at clinically relevant virus concentrations.•Low temperatures limit SARS-CoV-2 Ag-RDT specificity.•Storage and operation of SARS-CoV-2 Ag-RDTs at recommended conditions is essential.

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关键词

SARS-CoV-2,Rapid antigen test,Temperature stability,Sensitivity,Specificity,Tropics,Winter

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