Placental Based Contraceptive Vaccine

Disclosed are methods of preventing pregnancy through induction of immunological responses through vaccination with placental extracts and products associated with placentation. In one particular embodiment an immune response is triggered towards pregnancy associated neoangiogenesis through administration of placental endothelial cells capable of triggering immunity. In other embodiments the process of replicating immunological events associated with pregnancy failure are recapitulated by stimulation of immunity to antigens such as VEGFR-1, VEGFR-2, CD105, FGF1-R, Integrin αvβ3, and CD-248.