Vitamin C Deficiency And Oxidant Levels In Children With Transfusion-Dependent Beta-Thalassemia
Indian pediatrics(2021)
摘要
Objectives To study vitamin C levels in children with transfusion-dependent beta-thalassemia and correlate with age, transfusions received and iron overload; and to study the effect of administering vitamin C on its levels and Malondialdehyde (MDA) in deficient patients. Methods This case-control study enrolled 100 children with transfusion-dependent beta-thalassemia and 30 healthy controls. MDA levels before and after administration of vitamin C were performed randomly in 36 children with low vitamin C levels. Results 81/95 (85.3%) study subjects vs none in control group, had low plasma vitamin C levels (P<0.001). Vitamin C levels were low in 64 of 71 (74.7%) subjects with dietary deficiency, while none of the 19 (63.3%) controls with dietary deficiency had low levels (P=0.04). Increasing serum ferritin values correlated with vitamin C deficiency (P=0.02). The mean level of MDA reduced (P<0.001) with vitamin C supplementation. Conclusions Low levels of vitamin C are common in children with thalassemia. Dietary counseling along with supplementation with vitamin C, in those with low levels may prevent oxidative stress.
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关键词
Iron overload, Oxidative stress, Thalassemia, Scurvy, Supplementation
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