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A Molecular Lid Mechanism of K+ Channel Blocker Action Revealed by a Cone Peptide

Chandamita Saikia,Orly Dym,Hagit Altman-Gueta,Dalia Gordon,Eitan Reuveny,Izhar Karbat

Journal of Molecular Biology（2021）

Cited 6|Views9
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Abstract
•Conk-C3 is a novel Kunitz-type K+ channel blocker isolated from cone venom.•MD simulations suggest that Conk-C3 traps K+ ions in cryptic coordination sites.•This prediction is supported by mutagenesis and by electrophysiological assays.•The results provide a molecular description of K+ channel “lid-block” by an animal toxin.
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Key words
channel,cone toxin,molecular-dynamics,lid-block,pore-collapse
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