HLA-E–restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities

Hongbing Yang, Margarida Rei, Simon Brackenridge, Elena Brenna, Hong Sun, Shaheed Abdulhaqq, Michael K. P. Liu, Weiwei Ma, Prathiba Kurupati, Xiaoning Xu, Vincenzo Cerundolo, Edward Jenkins, Simon J. Davis, Jonah B. Sacha, Klaus Früh, Louis J. Picker, Persephone Borrow, Geraldine M. Gillespie, Andrew J. McMichael

Science Immunology（2021）

引用 27|浏览38

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摘要

CD8 + T cells that recognize a Gag peptide presented by HLA-E suppress HIV-1 replication in vitro.

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关键词

hiv-1 infection,vaccine opportunities,gag-specific

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