Mechanism of the lifespan extension induced by submaximal SERCA inhibition in C. elegans

•Submaximal SERCA inhibition with inhibitors or RNAi increases C. elegans lifespan.•Lifespan extension required functional mitochondria, and both AMPK and TOR pathways.•Instead, the insulin signaling pathway and the sirtuin pathway were not involved.•ER-mitochondria Ca2+ signaling may play a role in the aging process.•The SERCA pump may be a new pharmacological target to act on longevity.