Evaluation of Foetal Haemoglobin Status among Nigerian Patients with Sickle Cell Anaemia Using High Performance Liquid Chromatography.

N I Ugwu,E O Nna,C N Ugwu,O E Ogah,C Okike,R C Ikeagwulonu,U U Nnadozie,A J Madu,H C Okoye,I C Uzoma,C Alo,G C Ugwu, V N Ekpeagu, U I Okeke

West African journal of medicine（2021）

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摘要

Patients with HbSS have significantly higher HbF level than individuals with HbAS and HbAA. Foetal haemoglobin level tend to decrease with advancing age and higher in females. Increased HbF level may play a compensatory mechanism in sickling in HbSS, thus the use of agent that increase HbF level may improve clinical outcome.

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关键词

Foetal Haemoglobin, High Performance Liquid Chromatography, Sickle Cell Anaemia, sickle cell traits, normal adult haemoglobin

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