A validated surrogate analyte LC-MS/MS assay for quantification of endogenous cortisol in human whole blood

Karan Agrawal,Ramakrishna R Voggu,Daniel Pisek, Steven Becht,Ross Chudnovskiy, Géraldine Mercier Dufour,Cecilia Arfvidsson,C Eric Thomas

Journal of Pharmaceutical and Biomedical Analysis（2021）

引用 8|浏览1

暂无评分

摘要

•First known surrogate analyte-based assay for cortisol in human whole blood.•Fit-for-purpose LC-MS/MS method validated in accordance with FDA and EMA guidance.•Cortisol is stable in blood up to 25 h at RT, boding well for at-home collection.•Whole blood and plasma cortisol concentrations demonstrate promising compatibility.•First step towards supporting at-home sampling for cortisol in clinical trials.

查看译文

关键词

Cortisol,Whole blood,LC-MS/MS,Surrogate analyte,Supported liquid extraction,Bioanalysis

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要