Clinical study of VERU-111, an oral cytoskeletal disruptor in men with metastatic Castration Resistant Prostate Cancer (mCRPC) who failed an androgen receptor targeting agent

R. Getzenberg,M. C. Markowski,R. Tutrone,M. A. Eisenberger,C. Pieczonka,D. Rodriguez,K. G. Barnette,M. S. Steiner,D. R. Saltzstein,E. S. Antonarakis

JOURNAL OF CLINICAL ONCOLOGY（2021）

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摘要

131Background: VERU-111 is an oral, cytoskeletal disruptor that crosslinks α \u0026 s tubulin and inhibits microtubule polymerization with no affinity for multidrug resistance proteins. A Phase 1b/2 cli...

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关键词

Microtubule polymerization,Androgen receptor,Prostate cancer,Cytoskeleton,Cancer research,Medicine,Castration resistant,Clinical study,Multidrug Resistance Proteins,S tubulin

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