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Crystal Structures of NUDT15 Variants Enabled by a Potent Inhibitor Reveal the Structural Basis for Thiopurine Sensitivity.

Daniel Rehling,Si Min Zhang,Ann-Sofie Jemth,Tobias Koolmeister,Adam Throup,Olov Wallner,Emma Scaletti,Takaya Moriyama,Rina Nishii,Jonathan Davies,Matthieu Desroses,Sean G. Rudd,Martin Scobie,Evert Homan,Ulrika Warpman Berglund,Jun J. Yang,Thomas Helleday,Pal Stenmark

Journal of Biological Chemistry（2021）

引用 9|浏览40
关键词
NUDT15,NUDIX,hydrolase,MTH2,inhibitor,crystal structure
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