Discovery Of A Novel Class Of Inhaled Dual Pharmacology Muscarinic Antagonist And Beta 2 Agonist (Maba) For The Treatment Of Chronic Obstructive Pulmonary Disease (Copd)

The targeting of both the muscarinic and ?-adrenergic pathways is a well validated therapeutic approach for the treatment of chronic obstructive pulmonary disease (COPD). In this communication we report our effort to incorporate two pharmacologies into a single chemical entity, whose characteristic must be suitable for a once daily inhaled administration. Contextually, we aimed at a locally acting therapy with limited systemic absorption to minimize side effects. Our lung-tailored design of bifunctional compounds that combine the muscarinic and ?-adrenergic pharmacologies by the elaboration of the muscarinic inhibitor 7, successfully led to the potent, pharmacologically balanced muscarinic antagonist and ?2 agonist (MABA) 13.