Characteristics And Outcomes Of Covid-19 Infections In People Living With Hiv

Background: There is a paucity of data in the clinical characteristics and outcomes of PLWHIV diagnosed with COVID-19 infections This case series describes our experience of PLWHIV diagnosed with COVID-19 who received inpatient care from an HIV service in Manchester, UK Methods: Characteristics including demographics, duration of admission, symptoms, relevant investigations, use of antibiotics and outcome were recorded from March to July 2020 of patients with suspected or confirmed COVID-19 Data was retrospectively collected from electronic patient records (Table 1) Results: Sixteen PLWHIV were diagnosed with COVID-19 as an inpatient between March and July 2020 Twelve (75%) were admitted with COVID symptoms Four (25%) likely had hospital acquired infection, one of these was asymptomatic Twelve of 16 (75%) were Black Asian Minority Ethnic (BAME) group Comparatively, 31% of PLWHIV across the service are of BAME ethnicity Conclusions: Twelve of 16 (75%) individuals, who all had well-controlled HIV (viral load \u003c 200) at the time of COVID-19 diagnosis, recovered With age widely regarded as the greatest risk factor for adverse outcomes in those diagnosed with COVID-19, it is interesting that the COVID-related deaths were in individuals in their 50s Both were in men, one of black African and one white British ethnicity Both had a history of hypertension and presented with fever, shortness of breath and cough The two other deaths were in individuals in the terminal phases of cryptococcal meningitis and metastatic cancer In our cohort, black ethnicity, male gender, hypertension, raised BMI, cardiovascular disease and pre-existing renal disease were common As in the general population, black individuals were disproportionately affected The causes of this are multifactorial and require further exploration Over 43% of individuals experienced new renal impairment One patient had to switch ARVs (from FTC/TAF/DTG to DOR/3TC/DTG) PLWHIV are already at risk of adverse renal outcomes and it is important to follow these individuals up to establish the longterm sequelae Limited conclusions can be drawn due to the small size of the data pool, but this case series suggests that those with wellcontrolled HIV have similar outcomes to the general population