Association of Gene Polymorphisms of Some Endothelial Factors with Stent Reendothelization after Elective Coronary Artery Revascularization

Restenosis remains the main complication after percutaneous coronary interventions in patients with coronary heart disease. The causes of its development include, in particular, genetic factors. We studied polymorphic loci of genes encoding endothelin-1 ( EDN1 rs5370 ), endothelin-1 receptor ( EDNRA rs5333 ), endothelin-converting enzyme ( ECE1 rs1076669 ), and endothelial NO synthase ( eNOS rs1549758 , eNOS rs1799983 , and eNOS rs2070244 ) in the context of in-stent restenosis development. It was found that the analyzed polymorphisms of the endothelin system genes were more significant for patients aged ≥ 65 years, while the polymorphic loci of the endothelial NO synthase gene ( eNOS rs1799983 and eNOS rs1549758 ) were predominantly associated with time of in-stent restenosis. The obtained results can be useful for comprehensive assessment of the restenosis risk factors and the choice of optimal treatment for patients with coronary heart disease before elective surgical intervention.