Prednisone is genotoxic in mice and Drosophila melanogaster

Laís Camargo de Oliveira,Abel Vieira de Melo Bisneto,Sara Cristina Puga,Amanda Silva Fernandes,Jefferson Hollanda Véras,Clever Gomes Cardoso,Carolina Ribeiro e Silva,Cristiene Costa Carneiro,Lee Chen-Chen

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2021）

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摘要

•Prednisone showed potent genotoxic action in mouse bone marrow micronucleus test.•Prednisone demonstrated high genotoxic effect in comet assay in mice bone marrow cells.•Prednisone showed potent genotoxic action in D. melanogaster in SMART test.•Somatic recombination was the main genotoxic effect observed in SMART test.•Histopathological analysis showed no relevant toxicity of prednisone in mice tissues.

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关键词

Prednisone,Genotoxicity,SMART,Micronucleus test,Comet assay,Histopathological analyses

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