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The APOB polymorphism rs1801701 A/G (p.R3638Q) is an independent risk factor for early-onset coronary artery disease: Data from a Spanish cohort

Eliecer Coto,Rebeca Lorca,Julián Rodríguez-Reguero,María Martín,Isaac Pascual,Pablo Avanzas,Elías Cuesta-Lavona,Daniel Vázquez-Coto,Carmen Díaz-Corte,Salvador Tranche,Belén Alonso,Sara Iglesias,César Morís,Juan Gómez

Nutrition, Metabolism and Cardiovascular Diseases（2021）

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Abstract
•APOB gene variant rs1801701 (p.R3638Q) was associated with early-onset coronary artery disease.•APOB rs1801701 variant was associated with hypercholesterolemia.•The APOB variant was a risk factor for EO-CAD independent of hypercholesterolemia.
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Key words
Coronary artery disease,Atherosclerosis,APOB,Gene polymorphisms,Genetic association
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