Long-term ovarian hormone deprivation alters functional connectivity, brain neurochemical profile and white matter integrity in the Tg2576 amyloid mouse model of Alzheimer's disease

Neurobiology of Aging（2021）

引用 6|浏览19

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摘要

•Ovariectomy causes metabolic alterations in the hypothalamus in Tg2576 mice.•Ovariectomy alters cortical and sub-cortical resting state functional connectivity in Tg2576 and WT mice.•Ovariectomy alters white matter integrity in TG2576 mice.•The level of GFAP immunoreactivity and amyloid beta was not affected by ovariectomy.

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关键词

Alzheimer's disease,amyloid-beta (Aβ),functional connectivity,resting state fMRI,magnetic resonance spectroscopy,Diffusion Tensor Imaging,ovariectomy,ovarian hormones,Tg2576 mice,human APP Swedish,Astrocytes

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