Case Report: Metagenomics Next-Generation Sequencing Can Help Define The Best Therapeutic Strategy For Brain Abscesses Caused By Oral Pathogens
FRONTIERS IN MEDICINE(2021)
Abstract
Brain abscesses are associated with an increased long-term risk of new seizures and increased mortality within several years after infection. Common microorganisms that cause brain abscesses include bacteria, fungi, and mycoplasma. We report a 75-year-old man with a brain abscess caused by Prevotella denticola, an oral pathogen. Based on the clinical condition, we suspected that the patient had a blood-borne brain abscess, and he received antibiotics and systemic supportive treatment. The patient developed shock for the second time after negative Gram-staining results. Metagenomics next-generation sequencing showed one strain from the oral microbiome, confirming our hypothesis, and targeted antibiotic treatment was administered quickly. Thus, we report a case in which genomic analysis was the critical factor in determining the best antimicrobial therapy for administration.
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Key words
brain abscesses, oral microbiome, gram stain, metagenomics next-generation sequencing, precision treatment
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