The Relationship Between Hba1c Level And Endothelial Functions In Coronary Artery Disease

Objective: Endothelial dysfunction plays an important role in the development and prognosis of coronary artery disease. We aimed to evaluate the effects of glycolized hemoglobin (HbA1c), which is a parameter that shows the long-term mean glycemic index, on endothelial functions in coronary artery disease. Material and Method: 56 patients who has coronary artery disease documented by coronary angiography were included in this study. Endothelial functions were evaluated by flow-mediated vasodilation (FMD) test. IBM SPSS Statistics 25.0 program was used for statistical analysis. The suitability of numerical variables to normal distribution was examined with Kolmogorov Smirnov (n≥50) test. Spearman correlation analysis was used to evaluate the correlation between HbA1c and FMD percent change. Results: The average age of 56 patients included in this study was 61.5 ± 10.3 years. 71% of the patients are male, 29% of patients are female and mean body mass index is 27.52 ± 5.54 kg / m2. In the FMD test, the mean radial artery basal diameter was 0.25 (±0.028) cm, and the mean radial artery diameter after FMD was 0.28 (± 0.033) cm. A negative correlation was observed between HbA1c levels and the percentage change in artery diameter that was showed endothelial functions (r = - 0.306, p = 0.022). Conclusion: In coronary artery disease, HbA1c levels that showing long-term mean glycemic index can be considered as an independent factor in endothelial dysfunction.