1,3-Dibromo-5,5-Dimethylhydantoin (Dbh)/Dmso Mediated Oxidative Difunctionalization Of Styrenes: Microfluidic Synthesis Of Pentafluorophenoxy Ketone

A practical and mild synthesis of pentafluorophenoxy ketone in a continuous flow microfluidic reactor has been developed through 1,3-Dibromo-5,5-dimethylhydantoin (DBH)/DMSO mediated oxidative coupling of styrenes with pentafluorophenol. Moreover, a series of pentafluorophenoxy ketone products were provided in moderate to good yields under metal-free conditions. A magnifying continuous flow system was erected to verify the appliance of this method. (C) 2021 Elsevier Ltd. All rights reserved.