The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders

Mirta Milić,Marcello Ceppi,Marco Bruzzone,Amaya Azqueta,Gunnar Brunborg,Roger Godschalk,Gudrun Koppen,Sabine Langie,Peter Møller,João Paulo Teixeira,Avdulla Alija,Diana Anderson,Vanessa Andrade,Cristina Andreoli,Fisnik Asllani,Ezgi Eyluel Bangkoglu,Magdalena Barančoková,Nursen Basaran,Elisa Boutet-Robinet,Annamaria Buschini,Delia Cavallo,Cristiana Costa Pereira,Carla Costa,Solange Costa,Juliana Da Silva,Cristian Del Boˊ,Vesna Dimitrijević Srećković,Ninoslav Djelić,Malgorzata Dobrzyńska,Zdenka Duračková,Monika Dvořáková,Goran Gajski,Serena Galati,Omar García Lima,Lisa Giovannelli,Irina A. Goroshinskaya,Annemarie Grindel,Kristine B. Gutzkow,Alba Hernández, Carlos Hernández,Kirsten B. Holven,Idoia Ibero-Baraibar,Inger Ottestad,Ela Kadioglu,Alena Kažimirová,Elena Kuznetsova,Carina Ladeira,Blanca Laffon,Palma Lamonaca,Pierre Lebailly,Henriqueta Louro, Tania Mandina Cardoso,Francesca Marcon,Ricard Marcos,Massimo Moretti,Silvia Moretti,Mojgan Najafzadeh,Zsuzsanna Nemeth,Monica Neri,Bozena Novotna,Irene Orlow,Zuzana Paduchova,Susana Pastor,Hervé Perdry,Biljana Spremo-Potparević,Dwi Ramadhani,Patrizia Riso,Paula Rohr,Emilio Rojas,Pavel Rossner,Anna Safar,Semra Sardas,Maria João Silva,Nikolay Sirota,Bozena Smolkova,Marta Staruchova,Rudolf Stetina,Helga Stopper,Ekaterina I. Surikova,Stine M. Ulven,Cinzia Lucia Ursini,Vanessa Valdiglesias,Mahara Valverde,Pavel Vodicka,Katarina Volkovova,Karl-Heinz Wagner,Lada Živković,Maria Dušinská,Andrew R. Collins,Stefano Bonassi

Mutation Research/Reviews in Mutation Research（2021）

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摘要

•The alkaline comet assay is a popular methods for assessing DNA damage in humans.•A database of 19,320 subjects from 44 laboratories in 26 countries was analysed.•A range of measures estimating baseline DNA damage is provided for %T, TL, and TM.•None or limited effect was found for sex, age, and major confounding factors.•The comet assay efficiently detected specific genotoxic exposures.

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关键词

Comet assay,DNA damage,Pooled analysis,Human biomonitoring,Biomarkers

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