A Multicenter Evaluation of the US Prevalence and Regional Variation in Macrolide-Resistant S. pneumoniae in Ambulatory and Hospitalized Adult Patients in the United States.
Open Forum Infectious Diseases（2021）
Abstract
Macrolide resistance was found in 39.5% of 3626 nonduplicate isolates from adult ambulatory and inpatient settings at 329 US hospitals (2018-2019). Macrolide resistance was significantly higher for respiratory vs blood isolates and ambulatory vs inpatient settings. Despite geographic variation, macrolide resistance was >25% in most regions.
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Key words
Streptococcus pneumoniae,antibiotic resistance,community-acquired pneumonia,epidemiology,macrolides
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