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Diastereoselective Synthesis Of Hexahydropyrrolo[2,1-A]Isoquinolines By [3+2] Cycloaddition And Cyclative Heck Alkyne Hydroarylation

Guixiang Yang, Ye Liu,Liqun Wang,Yue Zhang,Xiaoming Ma,Wei Zhang

TETRAHEDRON LETTERS（2021）

Cited 3|Views9
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Abstract
Intermediates generated from three-component [3+2] cycloaddition of 2-bromobenzaldehydes and maleimides with amino esters or amino acids underwent N-propargylation and reductive Heck cyclization to form pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines. (C) 2021 Elsevier Ltd. All rights reserved.
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Key words
[3+2] Cycloaddition, Reductive heck cyclization, Alkyne hydroarylation, Hexahydropyrrolo[2,1-a]isoquinoline
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