Minimal change disease complicated by contrast-induced nephropathy

Abstract We present a clinical case with histopathological findings of an adult presentation of nephrotic syndrome complicated by acute kidney injury (AKI) following a CT contrast study. A 45-year old female with no significant past medical history was admitted following a 1 week history of peripheral oedema. She developed AKI following CT abdomen and pelvis with contrast, before being transferred to the renal team and being diagnosed with nephrotic syndrome. Histopathological assessment of a renal biopsy displayed evidence of both acute tubular injury and minimal change disease (MCD). To the author\u0027s knowledge, this is the first documented case of MCD complicated by contrast-induced nephropathy, with evidence of both pathologies on electron microscopy. Clinically, such cases emphasise the need for awareness of susceptibility to AKI in patients with MCD.