HEME: a neglected player in nociception?

Deborah Chiabrando,Veronica Fiorito,Sara Petrillo,Francesca Bertino,Emanuela Tolosano

Neuroscience & Biobehavioral Reviews（2021）

引用 7|浏览16

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摘要

•Heme regulates nociception.•Alteration of heme metabolism has been associated to pain insensitivity, acute and chronic pain in humans.•Defective heme metabolism may play a role in pain co-morbidities like ansia and depression.•The molecular mechanisms linking heme to the pain pathways are discussed.

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关键词

Heme,Nociception,Pain,FLVCR1,FLVCR1a,Sensory neurons

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