Review of zirconia-based biomimetic scaffolds for bone tissue engineering

Currently, biomimetic scaffold is one of the most promising strategies in the field of bone tissue engineering. Zirconia (ZrO 2 ), as a kind of bioceramic material, has attracted much attention in biomimetic scaffolds due to its excellent biocompatibility, high mechanical strength and great chemical stability. A lot of work has been carried out to investigate the characteristics and applications of the zirconia-based biomimetic scaffolds. However, there is few work which can provide a systematic comparison and overview on the research progress of zirconia-based biomimetic scaffolds. This review focuses on the properties and preparations of ZrO 2 and its composite materials. In addition, the roles of ZrO 2 along with other materials as scaffolds for bone tissue repair applications are highlighted. Simultaneously, the limitations of materials and technology are discussed. Graphical abstract