Optimization of oxygen plasma treatment of silicone implant surface for inhibition of capsular contracture

•Optimal O2 plasma treatment inhibited protein adsorption and bacterial adhesion.•Storage in DI water maintained hydrophilicity on O2 plasma-treated silicone surface.•Lower in vivo inflammation was seen in optimal O2 plasma-treated silicone implants.•Improved surface biocompatibility and reduced adverse immune responses were seen.•Optimal treatment is effective in attenuating excessive capsule formation.