442 Low ovarian response to stimulation and adverse perinatal outcome in fresh IVF embryo transfer cycles

Unlike maternal age, it is unclear whether the ovarian reserve alone has an impact on the obstetric outcome of pregnancies resulting from assisted reproductive technologies. We aimed to study the association between low ovarian response to gonadotropin stimulation and adverse perinatal outcome in singleton gestations. A retrospective cohort study of 382 women who underwent in-vitro fertilization and fresh embryo transfer and delivered a singleton neonate at a single center (pre-implantation genetic testing excluded). We examined the association between low ovarian response and adverse obstetric/perinatal outcomes. Patients were classified as: low responders - daily FSH≥300IU yielding ≤4 oocytes; normal responders 5-15 oocytes aspirated; high responders >15 oocytes aspirated; and sub-optimal treatment-daily FSH<300IU yielding ≤4 oocytes. Primary outcome was a composite of pre-eclampsia, gestational diabetes, small-for-gestational-age and delivery under 37 weeks. We compared maternal and neonatal outcomes between low responders and other groups. 27 women(7%) were categorized as low responders, 355(93%) as normal, high responders, or sub-optimal treatment. Maternal baseline characteristics were similar between groups except for increased maternal age and cycle number in low responders (36.15±3.74vs.30.7±4.9,p=