A Possible Association Between A Nucleotide-Binding Domain Lrr-Containing Protein Family Pyd-Containing Protein 1 Mutation And An Autoinflammatory Disease Involving Liver Cirrhosis

The nucleotide-binding domain leucine-rich repeat (LRR)-containing protein family pyrin domain (PYD)-containing protein 1 (NLRP1) forms an inflammasome complex with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and caspase-1. Inflammasome-activated caspase-1 cleaves pro-IL-1β or pro-IL-18 to produce its mature form and induces a type of cell death called pyroptosis through gasdermin D (GSDMD) activation.