DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody-Drug Conjugate Modality.
Prasanna Sivaprakasam,Ivar McDonald,Christiana Iwuagwu,Naidu S. Chowdari,Kevin M. Peese,David R. Langley,Heng Cheng,Michael R. Luzung,Michael A. Schmidt,Bin Zheng,Yichen Tan,Patricia Cho,Souvik Rakshit,Thirumalai Lakshminarasimhan,Sivakrishna Guturi,Kishorekumar Kanagavel, Umamaheswararao Kanusu,Ankita G. Niyogi, Somprabha Sidhar,Rajappa Vaidyanathan,Martin D. Eastgate,Srikanth Kotapati,Madhura Deshpande,Chin Pan,Pina M. Cardarelli,Chunshan Xie,Chetana Rao,Patrick Holder,Ganapathy Sarma,Gregory Vite,Sanjeev Gangwar ACS Medicinal Chemistry Letters（2021）
关键词
PBD,DNA minor groove binders,DNA binding models,ADC,cytotoxicity
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